Hello,
For anyone having the problem with Spine and Comodo, I found how to exclude it from comodo without having to uninstall.:

I added it in many classic exclusion list (like antivirus and firewall exclusion - full folder + .exe), but it seems that this last place (which is a litle "hidden") was the one that unblocked me :

Advanced protection > Misc > Do not detect injection of command in the following applications > add the Spine path.

Here you can see in screenshot that I manage to open application.
Sorry interface is in french, but you can adapt to your langage.

I hope it helps
(at least it will help me in the future because I already found it years ago and struggle again for two days after system reinstall xD)

Hello all,

I installed Bitdefender Total Security, and was able to get Spine to run after doing the following. I have also attached a screenshot of the exceptions list that I used in order to run Spine.

• Went to the link Mario posted to review the steps to add an exception to Bitdefender.
• Installed Bitdefender Total Security (the free trial).
• Allowed it to run a scan on installation to establish a baseline.
• Tried to open Spine to verify that it had interfered with Spine's operation; test was successful, I couldn't open Spine.
• Updated Bitdefender.
• Added Spine's installation folder to the exceptions list, and tried to open Spine. Still no dice.
• Opened the exceptions list again, and then added both the installation folder AND the exe itself inside that folder (so for me, C:\Program Files\Spine\Spine.exe) and verified that it was added to all 3 categories of the exceptions list: the Antivirus, Online Threat Protection, and the Advanced Threat Defense.

After that, I rebooted and verified that Bitdefender was running, and then opened Spine! I've had no problems opening projects or Spine itself. I tested using projects from different folders, etc.

I'm using Windows 10, Spine Professional 4.0.55, and the latest version of Bitdefender Total Security from their website.